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Reperfusion therapy helpsprevent infarct progression but is associated with thegeneration of reactive oxygen species, local inflam-matory and oxidant response to reperfusion, and open-ing of the mitochondrial permeability transition porethat extends infarct size beyond that observed dur-ing equivalent periods of ischemia alone (30). Similarly, Doyle, Danhauer, andEdgerton (1981) found that listeners with nor-mal hearing and those with hearing impairmentused the features of voicing, place, sibilance,and frication

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In the new network of contacts of the double mutant, the carbonyl oxy-gens of Gly245 and Met246 continue forming hydrogen bonds with an arginine,although this time with Arg168 from loop L2. Note the location ofthe myoepithelial cell process on the epithelial sideofthe basal lamina.The cytoplasm ofthe myoepithelial cell contains contractile filaments and densities (arrows) similar to those seen in smooth musclecells.The cell on the leftwith the small nucleus isa lymphocyte. This view has changed in recent yearsand rare diseases have received much more attention at the scienti?c, political, andsocietal level

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The cumulative accre-tion of volume within such units over the pressuretrajectory of the in?ation limb (i.e., the integralof the normal distribution) gives a sigmoid curveand lends to the in?ation limb its characteristicshape (Venegas et al.

This suggests a fundamental questioning of the utility of services fromthe perspective of users themselves.

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